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KMID : 0438219740110010469
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Korea University Medical Journal
1974 Volume.11 No. 1 p.469 ~ p.481
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A Study on Histological Changes in Gonads and Changes of the Amount of Water and Electrolyte Contents in Ovary, Uterus and Kidney of Immature Rabbits by Chlorpromzine Administration
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李根容/Lee, Keun Yong
李壽鍾/Lee, Soo Chong
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Abstract
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Chlorpromazine, one of the tranquilizers, has been used not only to the patients of toxemia of pregnancy but also to those of other conditions of gynecologic field. Although chlorpromazine is an excellent tranquilizer, it has a number of unwanted side effects.
The responses of chlorpromazine to the changes of the amount of water and electrolyte contents in the uterine and kidney tissue of immature female rabbits weighing from 1.5 to 2.0 kg. have been studied
The ovary of rabbits were observed grossly and microscopically after treat them with 50 I. U. /kg. of HCG. Another observation was made on the samples treated with 50mg/kg. of chlorpromazine plus 50 I. U. /kg. of HCG. All observations were carried out in 24 hours of conditioning.
Samples were dried in the oven at 100C, until the weight of the samples remained constant. Flame photometry was used for determination of sodium and potassium, Schales and Schales´ method for chloride, and Kovacs and Tarrnoky´s method for calcium and magnesium.
The results obtained are as follows:
1. The HCG treated rabbits showed remarkable . acceleration in maturation of the follicles and ovulation in the ovaries, while the chlorpromazine plus HCG treated group showed no obvious suppression in ovulation.
2. Changes in electrolyte levels in the serum of HCG treated rabbits showed an increase in potassium and magnesium levels and a decrease in chloride, sodium and calcium levels. In the chlorpromazine plus HCG treated group, on the contrary, potassium and magnesium showed a decrease in each level and calcium was increased in it´s level.
3. The contents of water and chloride in the uterine tissue of the HCG treated rabbits showed an increase, compared to that. of the normal group, but sodium, potassium and magnesium were decreased
r.:t
in each level
In comparing to group treated with HCG only, group treated with chlorpromazine plus HCG had decreased contents of water, chloride and magnesium but potassium and sodium were increased.
4. Calcium content in the kidney of the HCG treated group showed an increase and potassium was decreased. In the chlorpromazine plus HCG treated group, the contents of water, chloride, sodium and calcium were decreased, while magnesium content was increased compared to that of HCG treated group.
5. The contents of water in the kidney tissue of the normal, HCG treated, and chlorpromazine plus HCG treated groups were markedly increased compared to that of the uterine tissue.
6. Chloride contents in the kidney tissue of the normal and HCG treated groups showed lower level than that of the uterine tissue, on the other hand, no significant difference in chloride content was noted in both kidney and uterus of the chlorpromazine plus HCG treated group.
7. Sodium content in the kidney was lower than that of the uterus of the normal group and chlorpromazine plus HCG treated group, and higher in the HCG treated one.
& Potassium and calcium contents in the kidney were higher than that of the uterus of the normal group, of the HCG treated and chlorpromazine plus HCG groups.
9. Magnesium content in the kidney was lower than that of uterine tissue of the normal and HCG treated groups, while it was higher that of the kidney tissue of the chlorpromazine plus HCG treated group.
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KEYWORD
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